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Effect of risperidone on acute methamphetamine-induced hyperthermia in rats

Posted by Drug Rehab and Treatment on June 15, 2010 · Leave a Comment 

Publication year: 2010
Source: Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 10 June 2010

Katsutoshi, Shioda , Koichi, Nisijima , Tatsuki, Yoshino , Satoshi, Kato

The abuse of methamphetamine (METH) is popular in many parts of the world. The number of fatal cases related to METH-induced hyperthermia is increasing, but no definitive therapy has yet been found. In the present study, we investigated the ability of risperidone to attenuate acute METH-induced hyperthermia and the mechanism of its action. When administered before and after a single high METH dose (10mg/kg), risperidone significantly suppressed acute METH-induced hyperthermia in a dose-dependent manner. The same effect was produced by dopamine-1 (DA1) and serotonin-2A (5-HT2A) receptor blockers, but not by D2, 5-HT1A, 5-HT2B/2C, or 5-HT2C receptor blockers, demonstrating that risperidone…

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