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Effects of repeated tramadol and morphine administration on psychomotor and cognitive performance in opioid-dependent volunteers

Posted by Drug Rehab and Treatment on June 15, 2010 · Leave a Comment 

Publication year: 2010
Source: Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 9 June 2010

Miriam Z., Mintzer , Ryan K., Lanier , Michelle R., Lofwall , George E., Bigelow , Eric C., Strain

Tramadol is an atypical, mixed mechanism analgesic used to treat moderate to severe pain. Based on evidence that tramadol has relatively low abuse potential and can relieve opioid withdrawal, tramadol may be useful for treating opioid dependence. The purpose of this study was to assess the performance side-effect profile of tramadol. Nine opioid-dependent volunteers completed a performance battery following 5–7 days of subcutaneous morphine (15mg, 4 times/day) and two doses of oral tramadol (50, 200mg, 4 times/day) in a within subject cross-over design. Morphine was always the first condition, and the order of the two tramadol doses was randomized and…

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