Modafinil for the treatment of cocaine dependence☆

Publication year: 2009
Source: Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 26 June 2009
Ann L., Anderson , Malcolm S., Reid , Shou-Hua, Li , Tyson, Holmes , Lynn, Shemanski , …

 Aim: Modafinil was tested for efficacy in facilitating abstinence in cocaine-dependent patients, compared to placebo. Methods: This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 4-week follow-up. Six outpatient substance abuse treatment clinics participated in the study. There were 210 treatment-seekers randomized, having a diagnosis of cocaine dependence; 72 participants were randomized to placebo, 69 to modafinil 200mg, and 69 to modafinil 400mg, taken once daily on awakening. Participants came to the clinic three times per week for assessments and urine drug screens, and had one hour of individual psychotherapy weekly. The primary outcome measure was the weekly percentage…