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Open-label dose-finding trial of buprenorphine implants (Probuphine)® for treatment of heroin dependence

Posted by Drug Rehab and Treatment on April 30, 2009 · Leave a Comment 

Publication year: 2009
Source: Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 28 April 2009
Jason, White , James, Bell , John B., Saunders , Paul, Williamson , Maria, Makowska , …

Buprenorphine, a μ-opioid receptor partial agonist, has been shown to be safe and effective for treatment of opioid dependence. A novel implantable formulation of buprenorphine (Probuphine®), using a polymer matrix sustained-release technology, has been developed to offer treatment for opioid dependence while minimizing risks of patient noncompliance and illicit diversion. The goal of the current study was to conduct an initial, open-label, evaluation of the safety, pharmacokinetics, and efficacy of two doses of Probuphine in subjects with opioid dependence maintained on sublingual buprenorphine. Two doses of Probuphine were evaluated in 12 heroin-dependent volunteers switched from daily sublingual buprenorphine dosing to…

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